You may want to play the numbers game. What I mean by that is play a combo between man and zone. If your opponent is playing a twins formation where he has 2 receivers split out to the same side, try playing 3 over their 2.

Put your corner playing man on the number 1 receiver (outside one) along with a decent outside linebacker/strong safety over the number 2 receiver (the inside one).

Then play a cover 2 shell over the top with your free safeties. Thus the 3 over 2. If a receiver gets past one of your defenders, you have a free safety for support over the top.

You can play your safeties with inside leverage if you are playing someone who likes to slip in a run now and then. It helps to have good linebackers to free up your safeties for pass coverage.

Having a safety over the top can also free up one of your man to man cover guys to slip in a corner or outside linebacker blitz.

Good Luck.